Bioinformatics Research Analyst – Neurology

Bioinformatician Position

The Pottier Laboratory in the Department of Neurology at Washington University School of Medicine is recruiting a Bioinformatician to join our research on the genetics and transcriptomics of Alzheimer disease, frontotemporal dementia and related neurodegenerative disorders. The position focuses on single-nuclei RNA sequencing (snRNA-seq) of human brain, with additional work in whole-genome sequencing (short- and long-read).

You will work closely with the PI, postdocs, other computational scientists and clinical and neuropathology collaborators as part of the NeuroGenomics and Informatics (NGI) Center, a group of more than 20 computational and statistical researchers.

Primary Duties & Responsibilities:

• Implements: Algorithms and computer software for analyzing omics-based data sets [high-throughput, massively parallel genomic/proteomic/clinical]; Data management and analysis solutions that aid in the storage, investigation and dissemination of large data sets.
• Coordinates research project with other investigators and institutions.
• Participates in developing hypotheses and experimental design.
• Assists with reporting of methods, data and results.
• Process and analyze short- and long-read snRNA-seq data, including QC, clustering, cell-type annotation, differential expression and isoform-level analyses.
• Process and analyze short- and long-read WGS data, including QC, variant calling, structural variants and association analyses.
• Integrate transcriptomic and genetic data with clinical, neuropathological and proteomic data.
• Develop, maintain and improve reproducible pipelines on high-performance computing systems as data and tools change.
• Organize, back up and share data with collaborators and consortia.
• Advise team members and train and supervise junior scientists.
• Participate in lab and collaborator meetings.
• Contribute to manuscripts, grants and reports, including methods, results and figures.

Working Conditions:

• Works in a laboratory environment with potential exposure to biological and chemical hazards
• Must be physically able to wear protective equipment and to provide standard care to research animals
• Normal office environment.
• Typically sitting at desk or table.
• Repetitive wrist, hand or finger movement (PC Typing).
• Office equipment.

Required Qualifications:

Education: Bachelor's degree or combination of education and/or experience may substitute for minimum education.

Certifications /Professional Licenses : No specific certification/professional license is required for this position.

Work Experience: Relevant Experience (2 Years)

Skills: Not Applicable

Driver's License: A driver's license is not required for this position.

More About This Job:

WashU seeks highly motivated individuals who are able to perform duties in a manner consistent with our core mission and guiding principles.

Preferred Qualifications:

Education: Master's degree

Certifications /Professional Licenses : No additional certification/professional licenses unless stated elsewhere in the job posting.

Work Experience: No additional work experience unless stated elsewhere in the job posting.

Skills: Analytical Thinking, Bioinformatics Tools, Communication, Complex Data Analysis, Computational Biology, Critical Reasoning, Gene Expression Microarray, Genome Sequencing, Group Problem Solving, Human Genetics, Model Organism

Salary Range:

$41,700.00 – $75,600.00 / AnnuallyThe salary range reflects base salaries paid for positions in a given job grade across the University. Individual rates within the range will be determined by factors including one's qualifications and performance, equity with others in the department, market rates for positions within the same grade and department budget.

Benefits Statement:

• Up to 22 days of vacation, 10 recognized holidays, and sick time.
• Competitive health insurance packages with priority appointments and lower copays/coinsurance.
• Take advantage of our free Metro transit U-Pass for eligible employees.
• WashU provides eligible employees with a defined contribution (403(b)) Retirement Savings Plan, which combines employee contributions and university contributions starting at 7%.
• Wellness challenges, annual health screenings, mental health resources, mindfulness programs and courses, employee assistance program (EAP), financial resources, access to dietitians, and more!
• We offer 4 weeks of caregiver leave to bond with your new child. Family care resources are also available for your continued childcare needs. Need adult care? We've got you covered.
• WashU covers the cost of tuition for you and your family, including dependent undergraduate-level college tuition up to 100% at WashU and 40% elsewhere after seven years with us.

EEO Statement:

Washington University in St. Louis is committed to the principles and practices of equal employment opportunity. It is the University's policy to provide equal opportunity and access to persons in all job titles without regard to race, ethnicity or shared ancestry, color, national origin, citizenship (where prohibited by federal law), age, religion, sex, sexual orientation, gender identity or expression, disability, protected veteran status, or genetic information. As a federal contractor, the university maintains affirmative action programs to implement its equal employment opportunity policy for individuals with disabilities and protected veterans, in accordance with Section 503 of the Rehabilitation Act of 1973, as amended, and the Vietnam Era Veterans' Readjustment Assistance Act of 1974 (VEVRAA), as amended.

Tagged as: Life Sciences