Post Doctoral Fellow B - Vaccine Development and Global Health

Job Description

The University of Maryland, Baltimore (UMB), Center for Vaccine
Development and Global Health (CVD) brings together more than four
decades of innovative and life-saving research on vaccines and
infectious diseases. http://
www.medschool.umaryland.edu/cvd/ As an organized research
center within the University of Maryland School of Medicine
(UMSOM), CVD comprises a multi-disciplinary team of faculty and
staff whose primary mission is to develop, evaluate, and implement
vaccines and other interventions to reduce illness and mortality
domestically and in less developed countries. We work to prevent
and treat enteric and respiratory diseases, to reduce the threat of
malaria and antimicrobial resistance, and to identify, understand,
and combat other tropic and emerging pathogens burdening
low-resource settings. Training is a critical component of our work
to ensure the foundation for the next generation of scientists and
researchers committed to our mission.

The CVD is seeking a Post Doctoral Fellow to join Dr. Sztein’s
Laboratory.

Responsibilities

The Sztein Lab is seeking a motivated Postdoctoral Fellow that has
in depth study of immunity to enteric fevers caused by the
human-restricted Salmonella enterica serovar Typhi (ST, typhoid
fever) and serovar Paratyphi (SP, paratyphoid fever) which are
major public health concerns. Given the growing antimicrobial
resistance across the genus Salmonella, the generation of
multivalent enteric fever vaccines are urgently needed. Thus, in
depth studies of the immune response and which immune responses are
associated with protection are urgently needed. Your studies will
greatly extend major discoveries in Dr. Sztein’s laboratory during
the past 3 decades in understanding T- and B-cell-mediated immunity
(CMI) and innate immunity elicited by the licensed oral Ty21a and
other candidate S. Typhi vaccines, as well as controlled human
infection models. These studies will include system biology
approaches to integrate epigenetics and sc-RNAseq transcriptional
measurements and detailed immunological data (e.g., classical
T-CMI, B-CMI and unconventional T cells immunity) following
immunization or exposure to wild-type organisms with the ultimate
goal of uncover key immunological responses associated with
protection.

Qualifications

Qualifications

• PhD in Immunology, Cell Biology, Pharmacology, Molecular

Biology, or a related field.

• Demonstrated experience of immune responses to infectious

diseases and vaccines in different human populations including
pregnant women, newborns, infants, and adults

• Strong experience with research focused on immune mechanisms

that could prolong immunity from persistent infection via
vaccination.

Preferred Experience

Candidates with experience in immune responses to infectious
diseases and vaccines in different human populations including
pregnant women, newborns, infants, and adults will be especially
competitive.

The ideal candidate will have strong communication and
organizational skills, scientific independence, and an interest in
developing rigorous experimental systems.

About Us

The University of Maryland, Baltimore (UMB) is Maryland’s public
health, law, and human services university. Six professional
schools and the interdisciplinary Graduate School confer the
majority of health care, human services, and law professional
degrees in Maryland each year.

Our goal is to support the University’s mission of education,
research, clinical care, and public service by amplifying UMB’s
voice as a thought and action leader, and to enhance goodwill in
the communities and people with whom we engage. UMB is a public
university and constituent institution of the University System of
Maryland. All employees are expected to work primarily physically
within the State of Maryland.

UMB is committed to cultivating a diverse and inclusive workforce
and is proud to be an equal employment opportunity employer. All
qualified applicants will receive consideration for employment
without regard to race, color, religion, age, ancestry or national
origin, sex, pregnancy or related conditions, sexual orientation,
gender identity or expression, genetic information, physical or
mental disability, marital status, protected veteran's status, or
any other legally protected classification.

If you anticipate needing a reasonable accommodation for a
disability under the Americans With Disabilities Act (ADA), during
any part of the employment process, please submit a UMB Job Applicant Accommodation Request . You
may also contact HRDiversity@umaryland.edu. Please note that only
inquiries concerning an ADA request for reasonable accommodation
will be responded to from this email address.

The University of Maryland, Baltimore prohibits sex discrimination
in any education program or activity that it operates. Individuals
may report concerns or questions to the Title IX Coordinator. Read
the UMB Notice of Non-Discrimination for more
information.

UMB is a public university and constituent institution of the
University System of Maryland. All employees are expected to work
primarily physically within the State of Maryland. Regular and contractual employee are eligible for a
comprehensive benefits package

About the Team

The University of Maryland School of Medicine (SOM) was chartered
in 1807 as the first public medical school in the United States. It
continues today as one of the fastest growing, top-tier biomedical
research enterprises in the world. SOM is dedicated to providing
excellence in biomedical education, basic and clinical research,
quality patient care and service to improve the health of the
citizens of Maryland and beyond.