Postdoctoral Position in Leptin Gene Regulation and Adipocyte Biology

Postdoctoral Position in Leptin Gene Regulation and Adipocyte Biology
SDU - University of Southern Denmark
Odense, Denmark
Project and Research Environment
The Postdoctoral Fellow will work on a project focusing on the molecular mechanisms regulating human leptin (LEP) gene expression in adipocytes. The aim is to identify the cis-regulatory elements, transcription factors, and signaling pathways controlling LEP expression during adipocyte differentiation and in mature adipocytes, and to understand how chromatin architecture and physiological signals are integrated to regulate leptin production. To address these questions, the project combines complementary, state-of-the-art approaches, including:
Chromatin conformation analyses (e.g., Region-Capture Micro-C, Capture-C, and related approaches);
Epigenomic profiling (e.g., ATAC-seq, CUT&Tag, and DynaTag);
Genome editing and perturbation approaches (e.g., CRISPRi, CRISPR/Cas9, and siRNA-mediated knockdown);
Transcriptomic and multi-omics analyses;
Computational modelling of gene regulatory networks and integration with clinical and physiological data.
The project is embedded in an interdisciplinary research environment that combines molecular biology, functional genomics, computational biology, and translational studies in primary human adipocytes.

Job Description

The Postdoctoral fellow will drive experimental activities and contribute to the scientific development of the project. The position requires both independent work and close collaboration within the research group.
Key responsibilities include:
Designing and conducting experiments investigating the regulation of human leptin (LEP) gene expression;
Generating and analyzing transcriptomic, epigenomic, and chromatin conformation datasets;
Integrating multi-omics, physiological, and clinical data to identify regulatory networks governing leptin expression;
Implementing and optimizing advanced molecular, genomic, and computational methods in adipocyte model systems and primary human adipocytes.
In addition, the candidate will:
Contribute to supervision and mentoring of students;
Participate in preparation of scientific publications and dissemination of results;
Actively contribute to a collaborative, ambitious, and supportive research environment.

Qualifications

We are seeking a highly motivated candidate with a strong postdoctoral research profile and expertise in functional genomics and the molecular regulation of gene expression.

Required qualifications:

A PhD in molecular biology, genomics, biochemistry, or a related field;
Strong background and experimental skills in molecular biology, functional genomics, and transcriptional regulation;
Ability to independently drive research projects;
Strong collaborative and communication skills;
Proficiency in spoken and written English.
In addition, the following qualifications are relevant but not required:
Hands-on experience with adipocyte biology, metabolic research, or cellular differentiation systems;
Experience with chromatin conformation methods (e.g., Capture-C, Micro-C, Hi-C, or related approaches);
Experience with epigenomic and transcriptomic techniques (e.g., ATAC-seq, CUT&Tag, RNA-seq, or related sequencing-based assays);
Experience with analysis and integration of multi-omics datasets;
Experience with computational biology, bioinformatics pipelines, and R for data analysis and visualization;
Hands-on experience with genome editing and gene perturbation technologies (e.g., CRISPR/Cas9, CRISPRi, or RNA interference).
Apply Now
Deadline 2 December
Don't forget to mention EuroScienceJobs when applying.
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SDU - University of Southern Denmark