Postdoctoral Position in Leukemia Immunology and Metabolism

Postdoctoral Position in Leukemia Immunology and Metabolism
University of Basel
Basel, Switzerland
Your position
Research environment:
The successful candidate will lead an ambitious interdisciplinary project at the interface of leukemia biology, tumor immunology, and cellular metabolism. Our ongoing work shows that leukemia metabolism profoundly influences the tumor-immune crosstalk, shaping both recognition of leukemia cells by the immune system and immune cell phenotypes. The project will investigate how specific metabolic programs enable leukemia cells to adapt to therapeutic and immune pressure, alter leukemia-immune interactions, and create targetable vulnerabilities.
Research directions may include:
Metabolic adaptation of leukemia under therapeutic pressure;
Effects of leukemia-derived metabolites on immune-cell function and immune recognition;
Identification and functional validation of metabolic mechanisms and therapeutic targets.
Your responsibilities will include:
Designing, performing, and interpreting mechanistic experiments, including in vivo animal studies;
Establishing and adapting experimental approaches as required;
Analyzing and presenting scientific data;
Developing collaborative projects;
Mentoring PhD and MSc students;
Contributing to manuscripts, scientific meetings, and grant applications.
Experimental approaches in our group include in vivo leukemia and allogeneic hematopoietic stem cell transplantation models, liquid chromatography-mass spectrometry metabolomics and lipidomics, functional genomics and CRISPR screens, spectral flow cytometry, cell sorting, bulk, single-cell and spatial transcriptomics, and functional immune and metabolic assays.
Your profile
We are looking for an experimental scientist with strong intellectual curiosity, knowledge and practical expertise in tumor immnology, and an interest in mechanistic cancer research.
Applicants should have:
A PhD (or equivalent degree) in cancer biology, immunology, molecular biology, hematology, or a related discipline;
A strong conceptual and experimental background in tumor biology and/or immunology;
Substantial hands-on experience with in vivo mouse tumor models, ideally in hematological cancers, and willingness to perform animal experiments;
Extensive experience with (spectral) flow cytometry and molecular biology;
A strong experimental track record, ideally including a high-quality first-author publication;
The ability to independently design, execute, and interpret mechanistic experiments;
Excellent communication skills (in English) and the ability to work collaboratively in an interdisciplinary team.
Experience in leukemia research, tumor immunology, metabolism, CRISPR screening, or histology is an advantage but not required.
We are particularly interested in candidates who want to take intellectual ownership of an ambitious project, pursue mechanistic questions, and develop their own scientific profile at the interface of tumor immunology and metabolism.
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University of Basel