About the position
We are seeking a highly motivated postdoctoral fellow to join our laboratory at the National Eye Institute and investigate the molecular mechanisms of retinal ganglion cell (RGC) neuroprotection and axon regeneration, with a particular focus on small extracellular vesicles (sEVs).
Our research program investigates the mechanisms regulating RGC survival, axon regeneration, retinal circuit organization, and visual pathway connectivity. Our long-term goal is to develop innovative therapeutic strategies for glaucoma, a leading cause of irreversible blindness, and other optic neuropathies.
A major focus of our research is the development of sEV-based, cell-free therapies for RGC neuroprotection. Building on our established research foundation, we aim to elucidate the molecular mechanisms underlying the therapeutic effects of sEVs. Our multidisciplinary approach integrates molecular and cellular biology, transcriptomics, microRNA profiling, proteomics, metabolomics, electrophysiology, advanced imaging, and stem cell technologies.
The successful candidate will investigate the molecular mechanisms underlying sEV-mediated neuroprotection by analyzing and integrating existing transcriptomic, microRNA, proteomic, and metabolomic datasets from therapeutic sEV populations and recipient target cells. This work aims to identify key molecular pathways and intercellular signaling networks that regulate RGC resilience and vulnerability, reveal novel therapeutic targets, and advance strategies to preserve RGC survival, structural integrity, and function in glaucoma.
Qualifications and Eligibility
Candidates must hold a Ph.D., M.D./Ph.D., or equivalent doctoral degree in neuroscience, molecular biology, cell biology, biochemistry, or a related field, and have fewer than three years of postdoctoral experience. Recent doctoral graduates are strongly encouraged to apply.
A strong background in molecular biology, biochemistry, and/or cell biology is desirable. Experience in computational biology, bioinformatics, transcriptomic data analysis, or multi-omics data integration is also desirable. Familiarity with statistical analysis and programming for biological data analysis is an advantage. Experience with mouse handling and disease models, tissue collection, organoids, high-throughput methods, or advanced microscopy is welcome but not required.
U.S. citizens and permanent residents are eligible to apply. Foreign nationals may also be eligible, subject to NIH appointment requirements and applicable U.S. government restrictions. All appointments are subject to current NIH policies.
How to Apply
Please email the following materials to Dr. Stanislav Tomarev:
A cover letter describing your research interests and career goals. A current curriculum vitae, including a list of publications. Names and contact information for three professional references. Contact: Dr. Stanislav Tomarev
Email: tomarevs@nei.nih.gov
Employer: National Eye Institute, National Institutes of Health
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