Postdoctoral Research Fellow - Cellular Senescence in Lung Injury

Full Time: 35 hours per week

Fixed term: 6 months

The Opportunity:

Where discovery never stops. Be part of something bigger.

Here, you can continue to make a difference in everything around you. Take on new challenges, grow your career, be recognised for your contributions, and benefit from our commitment to your wellbeing. Be part of something bigger — where your work has real impact and your development matters. There are so many reasons to take your next step with us.

The University of Edinburgh is a world-class organisation. We look for the best in the field across all disciplines and provide a working environment where academics can develop their careers and passion for their chosen subject area. We offer the full range of academic roles and have a genuine focus on our students’ performance and wellbeing.

We are looking for a Postdoctoral Research Fellow - Cellular Senescence in Lung Injury. A postdoctoral research position defining the contribution of cellular senescence to lung injury and inflammation in translationally relevant human models will be funded by the Baillie Gifford Pandemic Science Hub (BG PSH) which was created with philanthropic support from Baillie Gifford and comprises scientists, clinicians, professional services staff and students united in a common goal to use human genetics and experimental medicine to rapidly find and test the effects of drugs. The successful candidate will use a novel, high content, image analysis-based cell painting assay to define characteristics of senescent cells and their response to known senolytic drugs. They will optimise this process for use as a high throughput screen to identify novel senolytic / senomorphic drugs from available drug libraries. The senolytic potential of lead candidate molecules will be tested in a clinically relevant human precision cut lung slice model of irradiation-induced senescence.

Your skills and attributes for success:

• Experience of preparing and working with working with human Precision Cut Lung Slices (PCLS).
• Extensive tissue culture experience, including established cell lines and primary cell culture and characterisation of cellular senescence.
• Imaging techniques including multiplex - IHC and ICC, live cell imaging and confocal microscopy.
• Assay development (including high throughput application) and standardisation
• Expertise in qRT-PCR and immunoassays including Flow Cytometry, ELISA/ cytokine bead array and Western blotting

People have always been at the heart of our work. As part of the University, you are a part of our community. We are looking for people with drive, determination, and a passion for what they do.

A career with us has a range of other benefits that can be tailored to your lifestyle:

• Professional development and subject matter expertise
• Opportunities to develop new skills and broaden your experience
• Leading-edge research
• Opportunities for publication

This post is full-time (35 hours per week); however, we are open to considering part-time working patterns. This role requires presence onsite for lab work and therefore hybrid work cannot be offered for this role.

Apply Before: 04/11/2026, 23:59

£41,064 to £48,822 per annum