Research Associate in Mycobacterial Biochemistry & Microbiology

Research Associate in Mycobacterial Biochemistry & Microbiology
University of York
York, United Kingdom
GBP 37,694 - 46,049 per year
The York Bioenergetics Lab (bioenergetics.site) works to understand how bacteria transduce energy to maintain themselves, grow, and power processes such as infection or biotransformation. The Lab is seeking a PDRA to further its research into Mycobacterium tuberculosis and the wider mycobacteria group. M. tuberculosis is the world’s deadliest pathogen, causing devastating disease for which treatments are poorly tolerated and extended in duration; additionally, antibiotic resistance is growing.
The lab uses remission spectroscopy to measure the electron occupancy of cytochromes as they power cells in vivo, allowing the response of the cells to new bioenergetic-targeting antibiotics to be measured (e.g. Harrison et al., 2025, Nature Communications). Supporting spectroscopy, the lab uses extensive membrane protein biochemistry and cryo-EM.
The PDRA will continue our work leveraging our bioenergetic expertise to understand how mycobacteria are affected by new antibiotics such as Q203, bedaquiline, and derivatives. Several projects are now at an advanced state and ready to be progressed to completion.
Skills, Experience & Qualifications needed
Undergraduate degree in biochemistry, microbiology, or related area
PhD in biochemistry, biophysics, bacteriology, or a related field, or equivalent experience
Knowledge of bioenergetics, biochemistry, and microbiology
Experience of culturing and genetically modifying bacteria, ideally mycobacteria
Experience of protein purification, ideally of membrane proteins
Ability and experience to develop research objectives, carry out individual and collaborative projects, planning and prioritising own work to meet deadlines
Highly motivated and professional with collaborative work ethic, committed to high quality research and a willingness to proactively support colleagues and students
Have, or will shortly have, published rigorous scientific findings and the ability to explain how these findings advance their field
Apply Now
Deadline 11 November
Don't forget to mention EuroScienceJobs when applying.
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University of York