Research Scientist, Karthick Lab, College of Med, Dept of Pharmacology, Physiology & Neurobiology

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than 53,600 students, 12,000 faculty and staff, and over 360,000
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key contributors to UC’s success.

Job Overview

As one of the oldest medical schools in the country, the
UC College of Medicine has a reputation for training best-in-class
health care professionals and developing cutting-edge procedures
and research that improves the health and clinical care of
patients.

A Research Scientist position is available in the
laboratory of Dr. Karthick Chella Krishnan (www.med.uc.edu/klab) in the
Department of Basic Biomedical Sciences, Division of Cardiovascular
Biology, Metabolism and Pharmacology, at the University of
Cincinnati College of Medicine. The K Lab conducts mechanistic
research at the intersection of mitochondrial biology, metabolism,
genetics, and sex differences, with projects spanning the liver,
adipose tissue, heart, and hippocampus.

The laboratory focuses on understanding how genetic
background and sex shape mitochondrial adaptation and dysfunction
and contribute to cardiometabolic disease. Current research areas
include mitochondrial subpopulations, sex-dependent metabolic
regulation, genetic determinants of mitochondrial function, and
organ-to-organ communication.

Essential Functions

• Perform in-depth studies of mitochondrial function and

metabolism using isolated liver mitochondria, primary or
immortalized liver cells, human iPSC-derived hepatic organoids, and
mouse models.

• Elucidate the molecular mechanisms regulating mitochondrial

function and metabolism in metabolic and cardiometabolic disease
using a combination of biochemical, molecular, cellular, and mouse
genetic approaches.

• The goal of this research is to understand how alterations in

mitochondrial function and metabolism contribute to disease
pathogenesis and to identify mechanisms that may provide new
insights into therapeutic approaches for the improvement of human
health.

Daily tasks will include:

• Independently designing and conducting research as required by

the faculty supervisor and in accordance with all institutional and
federal regulations;

• Modifying and adapting experimental protocols (i.e.,

troubleshooting), techniques and procedures to address
project-specific experimental challenges and requirements;

• Supporting the development of proposals and writing

research-related funding and grants;

• Analyzing and interpreting data, preparing research results and

written summaries in manuscript form for publications and in
graphics form for presentation at research meetings and for grant
proposals;

• Independently writing manuscripts and engaging in the

dissemination of research findings;

• Contributing to a collaborative laboratory environment by

training and mentoring student researchers in research methods and
laboratory procedures;

• Maintaining and ensuring compliance with applicable regulatory

protocols, laboratory records, and institutional requirements;

• Undergoing training in and developing proficiency with

mitochondrial physiology, cellular and molecular biology
techniques, metabolic phenotyping, laboratory instrumentation, and
data analysis relevant to the laboratory's research projects.

Required Education

• PhD in Biotechnology, Biochemistry, or related

field.

Physical Requirements/Work Environment

• Office environment/no specific unusual physical or

environmental demands.

Compensation and Benefits

UC offers an exceptional benefits package designed to
support your well-being, financial security, and work-life
balance. (UC
Benefits) Eligibility may vary by position and FTE
status. Highlights include:

Comprehensive Tuition
Remission

UC provides tuition remission for you and your eligible
dependents, covering tuition costs for nearly all undergraduate and
graduate programs offered by the university.

Robust Retirement Plans

As a UC employee, you won’t contribute to Social Security
(except Medicare). Instead, you’ll choose between state pension
plans (OPERS, STRS) or an Alternative Retirement Plan (ARP), with
UC contributing 14–18% of your salary based on position.

Real Work-Life Balance

UC prioritizes work-life balance with a generous time-off
policy, including:

Vacation and sick time

11 paid holidays and additional end-of-year paid time off
(Winter Season Days)

6 weeks of paid parental leave for new parents

Additional Benefits Include:

• Competitive salary based on experience
• Comprehensive health coverage (medical, dental, vision,

prescription)

• Flexible spending accounts & wellness

programs

• Professional development & mentorship

opportunities

To learn more about why UC is a great place to work,
please visit our Careers
Page.

UC is an E-Verify employer. If hired into this position,
you will be required to provide satisfactory proof of employment
eligibility by providing acceptable, original forms of
identification for employment verification via the Federal I-9
employment verification process. Click here
for a list of acceptable documents.

Important: To apply you must
create a profile and submit a complete job application through the
UC applicant portal. We
are unable to consider “easy apply” applications submitted via
other websites. For questions about the UC recruiting process or to
request accommodations with the application, please contact UC HR
at jobs@uc.edu.

Equal Opportunity Employer. Building a workplace
where all qualified applicants will receive consideration for
employment, including Individuals with Disabilities and Protected
Veterans.

REQ: 104466