Senior Research Scientist - Cell Biology and Tissue Models

Experience: Typically 3–6 years of relevant post-Ph.D. research or industry experience; demonstrated scientific independence and directly relevant expertise will guide assessment.

Key Responsibilities Perform biochemical, molecular and cell-based assays; analyse results and maintain complete laboratory records. Design controlled experiments with predefined objectives, appropriate comparators and biological replication; retain complete records and critically assess all findings. Establish, maintain and characterize human cellular, multicellular and 3D tissue models, including spheroids or organoids appropriate to the research question. Develop and qualify assays for biological activity in disease-relevant systems, drawing on expertise in inflammation, fibrosis and tissue repair. Characterize experimental materials using appropriate biochemical and molecular methods, and perform quantitative cell-based assays. Evaluate concentration-dependent and time-dependent responses, model reproducibility and tissue-relevant function alongside viability and appropriate controls. Work with colleagues to investigate assay variability, establish suitable controls and improve method reproducibility. Prepare technical reports, present findings and contribute to assay transfer and preclinical study documentation. Own experimental plans and milestones, maintain SOPs and technical reports, communicate findings clearly and mentor junior team members. Required Qualifications Ph.D. in Biotechnology, Cell Biology, Molecular Biology, Biochemistry, Bioengineering, Regenerative Medicine, Stem Cell Biology, Pharmacology, Neuroscience or a related life-science discipline. Preferred Experience Experience with quantitative imaging, molecular assays and integration of structural and functional readouts; assay transfer or collaboration with external research laboratories. Strong hands-on mammalian cell-culture, cell-biology and molecular-biology skills, with evidence of independent experimental design, troubleshooting and quantitative data interpretation. Ability to perform and interpret biochemical or molecular characterization alongside quantitative cell-based assays, with clear documentation and scientific communication. Demonstrated independent ownership of disease-relevant assay development, including hands-on establishment and characterization of at least one human 3D culture, spheroid, organoid or multicellular tissue model. Scientific depth in inflammation, fibrosis, tissue repair, neurobiology or a related area, with the ability to apply that expertise across experimental systems. Working understanding of cellular signalling, gene expression and molecular mechanisms relevant to cell-based research. Experience with organoid development, stem-cell differentiation or advanced human co-culture models. Experience with induced pluripotent stem cell (iPSC) maintenance and characterization, directed differentiation, or neuronal/glial cultures. Experience with extracellular-vesicle (EV) biology, biochemical characterization or functional and potency assays.

Role emphasis: Cell biology | Disease models | Organoid culture | Functional assays