Senior Scientist - High Throughput Screening

Senior Scientist - High Throughput Screening
Selvita
Kraków, Poland
We are seeking an experienced Senior Scientist – High Throughput Screening (HTS) to join our In Vitro Pharmacology Oncology team.
This role is ideal for a scientifically driven professional with strong hands-on experience in designing, executing, analyzing, and troubleshooting large-scale HTS campaigns. The primary focus will be on delivering HTS projects in a CRO environment, including campaigns involving 200,000+ compounds, while contributing to assay development, automation, and hit identification workflows.
The successful candidate will become a key HTS expert within the organization, supporting scientific excellence, data quality, process development, and collaboration across multidisciplinary project teams.
Key Responsibilities
High-Throughput Screening Leadership
Lead and execute large-scale biochemical and cell-based HTS campaigns in 384- and 1536-well formats, including campaigns involving 200,000+ compounds.
Define screening strategies, assay requirements, controls, and quality criteria.
Oversee campaigns from assay transfer and screening execution through hit identification and confirmation.
Ensure high-quality project delivery in line with timelines and client expectations.
Assay Development and Optimization
Develop, optimize, miniaturize, and validate biochemical and cell-based assays for HTS applications.
Transfer assays into automated, HTS-compatible formats.
Optimize assay robustness and performance and ensure high-quality screening data.-
Scientific and Technical Oversight
Interpret screening data, troubleshoot technical issues, and drive improvements in assay and screening performance.
Support hit triage, confirmation, counter-screening, and follow-up characterization.
Contribute to the development of new HTS approaches, technologies, and workflows.
Quality and Process Excellence
Ensure compliance with internal SOPs, quality standards, and documentation requirements.
Contribute to the development and continuous improvement of HTS processes, quality controls, and operational standards.
Cross-Functional and Client Collaboration
Collaborate with biology, chemistry, automation, and data science teams to support client projects.
Provide scientific input during project planning, study design, and proposal preparation.
Present project updates and scientific findings to internal stakeholders and external clients.
Act as an HTS subject matter expert within multidisciplinary project teams.
Mentoring
Mentor junior scientists and laboratory staff.
Provide technical guidance in assay development, screening execution, troubleshooting, and data interpretation.
Contribute to building HTS expertise across the organization.
Your Background
PhD in Biology, Biotechnology, Pharmacology, Molecular Biology, Biochemistry, or a related life science discipline.
Minimum 5 years of relevant industrial experience in biotechnology, pharmaceutical, or CRO environments.
Proven experience leading large-scale high-throughput screening campaigns, ideally involving 200,000+ compounds.
Strong hands-on experience in biochemical and/or cell-based assay development and optimization.
Experience with automated liquid handling and screening platforms.
Strong understanding of HTS assay quality, validation, experimental design, and data analysis.
Experience with hit identification, confirmation, and profiling workflows.
Experience working with electronic laboratory notebooks (ELN) and data management systems.
Excellent written and verbal communication skills in English.
Preferred Qualifications
Experience with Echo acoustic dispensing systems.
Experience with automated screening platforms and robotic workflows.
Experience working directly with external clients in a CRO environment.
Previous experience mentoring or supervising scientists.
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